The Scottish Intercollegiate Guidelines Network (SIGN) recommends Xylitol use.

SIGN was formed in 1993 with the objective is to improve the quality of health care for patients in Scotland by reducing variation in practice and outcome, through the development and dissemination of national clinical guidelines containing recommendations for effective practice based on current evidence.

The membership of SIGN includes all the medical specialties, nursing, pharmacy, dentistry, professions allied to medicine, patients, health service managers, social services, and researchers.

SIGN has included Xylitol recommendations in their section devoted to primary prevention of dental caries.

Primary prevention of dental caries

Keeping children's teeth healthy before disease occurs

• Dietary advice to patients should encourage the use of non-sugar sweeteners, in particular xylitol, in food and drink.
• Patients should be encouraged to use sugar-free chewing gum, particularly containing xylitol, when this is acceptable.